A 6-month-old boy and a 13-year-old girl were among four people shot in the South Loop.
The 23-year-old man was driving when someone in a passing car fired shots, striking him in his head, arm and torso.
The vehicles, which were both unoccupied, were struck when someone in a passing vehicle fired shots.
Harvey Smith was last seen driving a silver Lincoln MKZ Tuesday morning in the 100 block of North Waterman Avenue.
Officers were investigating the crash at 11:44 p.m.in the 3200 block of West Barry Avenue when shots were fired.