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Second HIV patient reportedly cured after stem cell transplant

Timothy Ray Brown poses for a photograph, Monday, March 4, 2019, in Seattle. Brown, also known as the "Berlin patient," was the first person to be cured of HIV infection, more than a decade ago. | AP Photo/Manuel Valdes

Timothy Ray Brown poses for a photograph, Monday, March 4, 2019, in Seattle. Brown, also known as the "Berlin patient," was the first person to be cured of HIV infection, more than a decade ago. | AP Photo/Manuel Valdes

SEATTLE — A London man appears to be free of the AIDS virus after a stem cell transplant, the second success including the “Berlin patient,” doctors reported.

The therapy had an early success with Timothy Ray Brown, a U.S. man treated in Germany who is 12 years post-transplant and still free of HIV. Until now, Brown is the only person thought to have been cured of infection with HIV, the virus that causes AIDS.

Such transplants are dangerous and have failed in other patients. They’re also impractical to try to cure the millions already infected.

The latest case “shows the cure of Timothy Brown was not a fluke and can be recreated,” said Dr. Keith Jerome of Fred Hutchinson Cancer Research Center in Seattle who had no role. He added that it could lead to a simpler approach that could be used more widely.

The case was published online Monday by the journal Nature and will be presented at an HIV conference in Seattle.

The patient has not been identified. He was diagnosed with HIV in 2003 and started taking drugs to control the infection in 2012. It’s unclear why he waited that long. He developed Hodgkin lymphoma that year and agreed to a stem cell transplant to treat the cancer in 2016.

With the right kind of donor, his doctors figured, the London patient might get a bonus beyond treating his cancer: a possible HIV cure.

The patient received the stem cell transplant from a donor with a rare CCR5 mutation that allows HIV resistance. About 1 percent of people descended from northern Europeans have inherited the mutation from both parents and are immune to most HIV. The donor had this double copy of the mutation.

That was “an improbable event,” said lead researcher Ravindra Gupta of University College London. “That’s why this has not been observed more frequently.”

The transplant changed the London patient’s immune system, giving him the donor’s mutation and HIV resistance.

The patient voluntarily stopped taking HIV drugs to see if the virus would come back.

Usually, HIV patients expect to stay on daily pills for life to suppress the virus. When drugs are stopped, the virus roars back, usually in two to three weeks.

That didn’t happen with the London patient (who is remaining anonymous). He took antiretroviral therapy drugs for HIV until September of 2017, doctors say. He has been HIV-free, in remission, for 18 months, according to tests.

Brown said he would like to meet the London patient and would encourage him to go public because “it’s been very useful for science and for giving hope to HIV-positive people, to people living with HIV,” he told The Associated Press Monday.

Stem cell transplants typically are harsh procedures which start with radiation or chemotherapy to damage the body’s existing immune system and make room for a new one. There are complications too. Brown had to have a second stem cell transplant when his leukemia returned.

Compared to Brown, the London patient had a less punishing form of chemotherapy to get ready for the transplant, didn’t have radiation and had only a mild reaction to the transplant.

Dr. Gero Hutter, the German doctor who treated Brown, called the new case “great news” and “one piece in the HIV cure puzzle.”

CARLA K. JOHNSON, AP Medical Writer