A container of Nexletol. In a major study, the drug reduced the risk of heart attacks and other health problems in people who can’t take drugs called statins, the main cholesterol-lowering treatment.

In a major study, Nexletol reduced the risk of heart attacks and other health problems in people who can’t take drugs called statins, the main cholesterol-lowering treatment.

Esperion Therapeutics

New pill cuts cholesterol, heart attacks — and it’s not a statin

Nexletol also blocks cholesterol production in the liver but in a different way than statins and without the muscle pain that can be a side effect of taking statins.

Drugs known as statins are the first-choice treatment for high cholesterol, but millions of people who can’t or won’t take those pills because of side effects could have another option.

In a major study, a different kind of cholesterol-lowering drug, named Nexletol, reduced the risk of heart attacks and some other cardiovascular problems in people who can’t tolerate statins, researchers have found.

Doctors already prescribe the drug, known chemically as bempedoic acid, to be used with a statin to help certain high-risk patients further lower their cholesterol. The new study tested Nexletol without the statin combination — and offers the first evidence that on its own it also reduces the risk of cholesterol-caused health problems.

Statins remain “the cornerstone of cholesterol-lowering therapies,” said Dr. Steven Nissen of the Cleveland Clinic, who led the study.

But people who can’t take those proven pills “are very needy patients,” Nissen said. “They’re extremely difficult to treat.”

This option “will have a huge impact on public health,” he said.

Too much so-called LDL or “bad” cholesterol can clog arteries and lead to heart attacks and strokes. Statin pills like Lipitor and Crestor — or their cheaper generic equivalents — are the mainstay for lowering LDL cholesterol and preventing heart disease or treating those who already have it. They work by blocking some of the liver’s cholesterol production.

But some people suffer serious muscle pain from statins. While it’s not clear exactly how often that occurs, by some estimates 10% of people who’d otherwise qualify for the pills can’t or won’t take them. They have limited options, including pricey cholesterol-lowering shots and another kind of pill, sold as Zetia.

Nexletol also blocks cholesterol production in the liver but in a different way than statins and without that muscle side effect.

The new, five-year study tracked nearly 14,000 people who were unable to tolerate more than a very low dose of a statin. Half got daily Nexletol and half a dummy pill.

The main finding: Nexletol-treated patients had a 13% lower risk of a group of major cardiac problems. Then, the researchers teased apart those different conditions and found a 23% reduced risk of a heart attack — the biggest impact. The drug also cut by 19% procedures to unclog arteries. There wasn’t a difference in deaths, which the researchers couldn’t explain but said might require longer to detect.

The findings were published in the New England Journal of Medicine and presented at a meeting of the American College of Cardiology. The study was funded by Nexletol maker Esperion Therapeutics.

The results are “compelling,” Dr. John H. Alexander of Duke University, who wasn’t involved with the study, wrote in the journal, and “will and should” spur use of the drug by patients unwilling or unable to take statins.

“It is premature, however, to consider bempedoic acid as an alternative to statins,” Alexander said. “Given the overwhelming evidence of the vascular benefits,” statins remain the top choice for most patients.

The Latest
Despite getting into foul trouble, which limited him to just six minutes in the second half, Shannon finished with 29 points, five rebounds and two assists.
Cowboy hats, bell-bottoms and boots were on full display Thursday night as fans lined up for the first of his three sold-out shows.
The incident occurred about 3:40 p.m. near Minooka. The horse was successfully placed back into the trailer, and the highway reopened about 40 minutes later. No injuries were reported.
The Hawks conceded the game’s only two goals within the first seven minutes and were shut out for the 12th time this season in a 2-0 defeat Thursday.