White Sox designate pitcher Odrisamer Despaigne for assignment

BOSTON — The White Sox are down to three starting pitchers after designating 32-year-old right-hander Odrisamer Despaigne for assignment Monday.

The Sox also activated outfielder Jon Jay from the 60-day injured list after he completed his rehab assignment with Class AAA Charlotte. Jay made his Sox debut, starting in right field and batting sixth against the Red Sox.

Despaigne, a failed attempt to fill a vacancy in a rotation that already had lost left-hander Carlos Rodon to Tommy John surgery, right-hander Ervin Santana to ineffectiveness and right-hander Dylan Covey to a sore shoulder, had a 9.45 ERA in three starts — the exact number posted by Santana — after being signed May 18. He allowed four runs and eight hits in three-plus innings Saturday against the Rangers.

Manager Rick Renteria said Tuesday will be a bullpen day, with right-hander Carson Fulmer getting the start. Covey, who will make a rehab start soon for Charlotte, should be back before long, and left-hander Hector Santiago, whom the Sox signed to a minor-league deal over the weekend, is starting Tuesday for Charlotte.

‘‘We’ve got to take it one day at a time [with Covey], and then we’ll determine what we’ll do as he’s continuing to recover and gets his outings under his belt,’’ Renteria said. ‘‘We want to make sure we take a measured approach to bringing him back.’’

Jay, Alonso reunited

Jay, whom the Sox signed to a one-year, $4 million deal in the offseason, finally played for them after dealing with a strained right hip and a groin injury that occurred during spring training. He batted .333 (21-for-63) in 16 rehab games between Class AA Birmingham and Charlotte.

Jay, 34, batted .268/.330/.347 with three home runs in a combined 143 games with the Diamondbacks and Royals last season. He posted a .374 on-base percentage in 433 plate appearances with the Cubs in 2017.

With Jay in right and Yonder Alonso at designated hitter, it marked an on-field reunion of friends from Miami, whom the Sox acquired in part as a way of trying to entice free-agent infielder Manny Machado to sign with them during the offseason.

‘‘It’s going to be exciting for me,’’ Jay said. ‘‘It’s something we got to do as college kids [at Miami], as high school kids. Now to do it in the big leagues is pretty special.’’

Moncada returns

Third baseman Yoan Moncada’s second trip to Fenway Park, where he broke in briefly with the Red Sox in 2016, came with less fanfare than his first did last season.

Moncada also is performing better in his second full big-league season, entering the game with a .295/.347/.509 hitting line to go with 12 homers and 40 RBI. He got the Sox on the board with a two-run homer against left-hander Eduardo Rodriguez in the second inning, his first round-tripper of the season batting right-handed.

‘‘I’ve improved overall in all aspects as a ballplayer,’’ said Moncada, who was 4-for-19 with 12 strikeouts for the Red Sox in 2016.

Collins’ usage

Renteria indicated rookie Zack Collins will make his second big-league start behind the plate Tuesday. He is working before games at first base, too.