Selena Lott scored 25 points, Camryn Taylor added 20, combining for 37 in the second half, and Marquette defeated DePaul 85-71 on Wednesday at Wintrust Arena.
Chloe Marotta added 16 points and Jordan King 13 for the Golden Eagles (17-4, 14-3 Big East), who have won six straight with their first win over a ranked team since beating DePaul at the end of last season. The win clinched the No. 2 seed for the conference tournament next weekend.
Lott scored 20 points and Taylor 17. on 7-for-7 shooting. as Marquette shot 70% (21 of 30) in the second half to break away from a 33-33 halftime tie.
Lexi Held scored 23 points for the Blue Demons (16-5, 13-4), who have lost back-to-back games to unranked teams. DePaul shot 38.9% after shooting 38.2% in an 83-72 loss to Creighton. Sonya Morris added 18 points. Deja Church, who had a career-high 24 points when the Blue Demons won the first matchup 87-82, had 10 points.
Lott scored 14 points on 5-of-7 shooting and four free throws in the third quarter when Marquette opened a 63-56 lead. Taylor had 12 points in the fourth quarter, including six straight, after the Blue Demons got within five.
Taylor also grabbed 11 rebounds to help Marquette to a 50-27 advantage on the boards, which helped translate to a 66-36 difference for points in the paint.
DePaul goes to Providence on Sunday and wraps up the regular season at home on Monday against Butler. Marquette is scheduled to end the season Monday at top-ranked UConn.